The School of Nursing accepted its first student in 1901. At that time the Hospital was still known as McKees Rocks General Hospital. Through out the years, the School of Nursing has grown and advanced with the Hospital toward a mutual goal of excellence in health care and nursing education. The School of Nursing has maintained programs of affiliation with other hospitals prominent in their respective fields to provide students with opportunities for experience in all areas of nursing care.

Since 1901 the School of Nursing has evolved from a three year program to a twenty month accelerated program. This provides an opportunity for non-traditional students to achieve quality nursing education in the least amount of time. Ohio Valley General Hospital School of Nursing has strong affiliation with a leading university in the area to incorporate the highest level of educational experience.